Characterization of ECM expression-regulating miRNAs in human focal epilepsy

 

 

 

Evidence is accumulating supporting the contribution of dysregulation in expression or activity of ECM molecules to pathological plasticity in the brain of patients with developmental epileptogenic lesions, as well as in patients with acquired forms of epilepsy. MicroRNAs (miRNAs) represent new class of post-transcriptional regulators of numerous biological processes within the central nervous system. miRNAs regulating different components of the ECM have been recently identified. In this project we aim: to characterise, at the cellular level, ECM expression-regulating miRNAs deregulated in different human epileptic disorders, and to identify ECM expression-regulating miRNAs as peripheral biomarkers of epileptogenesis.

 

 

Supervisor: Eleanora Aronica (or someone with similar expertise)

 

 

For more information about the post and to submit your application, please go to

https://www.amc.nl/web/Het-AMC/Werken-in-het-AMC/Vacatures/Vacatureoverzicht/AMR657W.htm

 

For details about the post, please contact:

Eleonora Aronica