Elucidation of causality between αV integrin deficiency and epilepsy

 

 

 

Elucidation of causality between αV integrin deficiency and epilepsy

 

Deficiencies in αV integrins lead to axonal degeneration, ataxia and epileptic seizures. We hypothesize that an αV integrin-dependent reduction in axonal projections alters the ratio of excitation to inhibition and/or triggers homeostatic hyper-excitability, thus leading to spontaneous seizures. In this project, we aim (1) to characterize the cellular and molecular defects of αV conditional KO (cKO) mice; (2) to assess whether morphological and/or physiological defects can be reversed by viral approaches; (3) to verify the role of the above studied mechanisms for epileptogenesis in vivo.

 

Supervisor: Lorenzo Cingolani

 

For more information about the post and to submit your application, please go to

http://www.iit.it/en/openings/research-departments/neuroscience-and-brain-technolgies/2850-call-for-european-marie-curie-fellow-lorenzo-cingolanis-group-marie-skodowska-curie-actions-european-innovative-training-network-h2020-msca-itn-2014-project-642881-qthe-extracellular-matrix-in-epileptogenesisq-ecmed.html

 

 

For details about the post, please contact: Lorenzo Cingolani