Development of Multielectrode array-based in vitro and ex vivo models of epileptogenesis and seizures for primary drug screening

 

 

For rapid initial evaluation of extracellular matrix (ECM)-targeting treatments, multielectrode array (MEA)-based neurointerfaces provide an invaluable research tool for high-throughput and high-content accessing neuronal activity in-vitro, on dissociated cell cultures or brain slices with planar electrode morphologies. MEA extracellular recordings are non-invasive, have a high signal-to-noise ratio and permit high resolution monitoring of changes in excitability and spread of excitation to test anti-epileptogenic ECM targeting drugs in various mice models of epilepsy. In this project, we will be testing reagents that target the ECM: (1) on electrical activity of primary neurons and ex vivo brain slices. (2) on seizure activity in experimental models of primary ECM pathology and (3) in acute brain slices from animal models of epilepsy and brain damage. 

 

 

Supervisor: Fabio Benfenati 

 

 

 

 

For more information about the post and to submit your application, please go to

http://www.iit.it/en/openings/research-departments/neuroscience-and-brain-technolgies/2849-call-for-european-marie-curie-fellow-fabio-benfenatis-group-marie-skodowska-curie-actions-european-innovative-training-network-h2020-msca-itn-2014-project-642881-qthe-extracellular-matrix-in-epileptogenesisq-ecmed.html

 

 

For details about the post, please contact: Fabio Benfenati