Role of LGI1 in the expression and treatment of acquired epilepsy

 

 

LGI1 is an excreted protein that is necessary for the function and trafficking of presynaptic Kv1.1 and also for the trafficking of AMPA receptors. Mutations in the gene encoding LGI1 result in epilepsy in humans and autoantibodies to LGI1 cause seizures and limbic encephalitis in humans. We have recently found LGI1 to be reduced in acquired epilepsy in animals and this is associated with a loss of function of presynaptic potassium channels. In this project, we will determine: if loss of LGI1 is sufficient to cause epilepsy; the mechanisms by which loss LGI1 results in epilepsy, and whether redressing this is an effective antiepileptogenic strategy. The project will use a combination of molecular and neurophysiological methods, in vivo and in vitro.

 

 

Supervisors: Matthew Walker and Elodie Chabrol

 

 

For more information about the post and to submit your application, please go to http://tinyurl.com/ecmedUCLesr

 

For details about the post, please contact: Matthew Walker and Elodie Chabrol